op_fwer_ord {gsMAMS}

Provides operating characteristics of group sequential MAMS trial for ordinal outcome under null hypothesis

Description

Computes FWER and other characteristics for group-sequential MAMS trial for ordinal outcome.

Usage

op_fwer_ord(alpha, beta, p, frac, or0, or, nsim, prob, seed)

Arguments

alpha

numeric Type I error.

beta

numeric Type II error.

p

numeric Number of treatment arms.

frac

numeric vector of fractions for information time at each look.

or0

numeric Odds ratio of ineffective treatment group vs control.

or

numeric Odds ratio of effective treatment group vs control.

nsim

numeric Number of simulations.

prob

numeric Probability of ordinal outcomes in control group.

seed

numeric Random seed number.

Value

A list of FWER, stage-wise type I error, average sample size used per arm, stopping probability, probability of futility.

Examples

op_fwer_ord(alpha = 0.05,
            beta = 0.1,
            p = 4,
            frac = c(0.5, 1),
            or0 = 1.32,
            or = 3.06,
            nsim = 15,
            prob = c(0.075, 0.182, 0.319, 0.243, 0.015, 0.166),
            seed = 13)