design_ord {gsMAMS}

Design the clinical trial for ordinal outcome

Description

This function generates the design parameters of a clinical trial for ordinal outcome.

Usage

design_ord(alpha, beta, k, prob, or0, or, frac)

Arguments

alpha

numeric Type I error.

beta

numeric Type II error.

k

numeric Number of treatment arms.

prob

numeric Probability of ordinal outcomes in control group.

or0

numeric Odds ratio of ineffective treatment group vs control.

or

numeric Odds ratio of effective treatment group vs control.

frac

numeric Vector of fractions for information time at each look.

Value

List of cumulative sample size for each stage of treatment and control groups along with maximum total sample size of the trial. It also provides efficacy and futility boundaries of the trial.

Examples

design_ord(alpha = 0.05,
           beta = 0.1,
           k = 4,
           prob = c(0.075, 0.182, 0.319, 0.243, 0.015, 0.166),
           or = 3.06,
           or0 = 1.32,
           frac = c(1 / 2, 1))