odds_ratio_function {genpwr}

Odds Ratio Function

Description

Calculates the odds ratio for a given power, at a given sample size, N, with type 1 error rate, Alpha

Usage

odds_ratio_function(
  N = NULL,
  Case.Rate = NULL,
  k = NULL,
  MAF = NULL,
  power = NULL,
  risk_allele = TRUE,
  Alpha = 0.05,
  True.Model = "All",
  Test.Model = "All"
)

Arguments

N

Vector of the desired sample size(s)

Case.Rate

Vector of the proportion(s) of cases in the sample (cases/(cases + controls)). Either k or Case.Rate must be specified.

k

Vector of the number of controls per case. Either k or Case.Rate must be specified.

MAF

Vector of minor allele frequencies

power

Vector of powers to detect

risk_allele

Logical: If OR > 1, the allele is classified as a "risk allele"

Alpha

the desired type 1 error rate(s)

True.Model

A vector vector the true underlying genetic model(s): 'Dominant', 'Additive', 'Recessive' or 'All'

Test.Model

A vector specifying the assumed genetic model(s) used in testing: 'Dominant', 'Additive', 'Recessive' or 'All'

Value

A data frame including the odds ratios for all combinations of the specified parameters

Examples

or <- odds_ratio_function(N=c(100), Case.Rate=0.3, 
 k=NULL, MAF= 0.25, power=0.8, 
 Alpha = 0.05, risk_allele = TRUE, True.Model = 'All', Test.Model = 'All')