gen2stage-package {gen2stage}

Generalized Two-Stage Designs for Phase II Single-Arm Studies

Description

The R package gen2stage can generate single-stage and two-stage designs for phase II single-arm efficacy or safety studies.

Details

Package:	gen2stage
Type:	Package
Version:	1.0
Date:	2017-10-05
License:	GPL-2

Author(s)

Seongho Kim <[e-mail]>

References

Kim S and Wong WK. Phase II Two-Stage Single-Arm Clinical Trials for Testing Toxicity Levels. Commun Stat Appl Methods. 2019 Mar;26(2):163-173. https://www.ncbi.nlm.nih.gov/pubmed/31106162.

Examples

  # Single-stage safety design with pu (p0) = 0.33 vs. pa (p1) = 0.20
  gen2single(0.33, 0.20, 0.05, 0.20)

  # Single-stage efficacy design with pu (p0) = 0.67 vs. pa (p1) = 0.80
  gen2single(0.67, 0.80, 0.05, 0.20)

  # save and print
  safety1 = gen2single(0.33, 0.20, 0.05, 0.20)
  print(safety1)

  # Two-stage safety design with pu (p0) = 0.33 vs. pa (p1) = 0.20
  gen2simon(0.33, 0.20, 0.05, 0.20)
  gen2simon(0.33, 0.20, 0.05, 0.10, nmax=150)

  # Two-stage efficacy design with pu (p0) = 0.67 vs. pa (p1) = 0.80
  gen2simon(0.67, 0.80, 0.05, 0.20)
  gen2simon(0.67, 0.80, 0.05, 0.10, nmax=150)

  # save, print and plot
  safety2 = gen2simon(0.33, 0.20, 0.05, 0.20)
  print(safety2)
  plot(safety2)