sample_size {frequentistSSD}

Calculate the sample size for each arm

Description

Calculate the sample size for each arm in a two-arm trial

Usage

sample_size(kappa, mA, hr, ta, tf, diff, P)

Arguments

kappa

the shape parameter of weibull distribution

mA

the median survival time of arm A

hr

the hazard ratio of arm B to arm A

ta

the accrual duration

tf

the follow-up duration

diff

the equivalence margin

P

the chance of correctly selecting the superior arm

Value

sample_size() returns required sample size for each arm

Author(s)

Chia-Wei Hsu, Haitao Pan, Jianrong Wu

References

Jianrong Wu, Haitao Pan, Chia-Wei Hsu (2021). "Two-Stage Screened Selection Designs for Randomized Phase II Trials with Time-to-Event Endpoints." Submitted

Examples

sample_size(kappa = 1, mA = 2.4, hr = 0.60, ta = 24,
            tf = 3, diff = 0.25, P = 0.9)