cgd {frailtyHL}

Chronic Granulomatous Disease (CGD) Infection Data

Description

The CGD data set in Fleming and Harrington (1991) is from a placebo-controlled randomized trial of gamma interferon in chronic granulomatous disease. In total, 128 patients from 13 hospitals were followed for about 1 year. The number of patients per hospital ranged from 4 to 26. Each patient may experience more than one infection. The survival times (times-to-event) are the times between recurrent CGD infections on each patient (i.e. gap times). Censoring occurred at the last observation for all patients, except one, who experienced a serious infection on the date he left the study.

Usage

data("cgd")

Format

A data frame with 203 observations on the following 16 variables.

id

Patient number for 128 patients

center

Enrolling center number for 13 hospitals

random

Date of randomization

treat

Gamma-interferon treatment(rIFN-g) or placebo(Placebo)

sex

Sex of each patient(male, female)

age

Age of each patient at study entry, in years

height

Height of each patient at study entry, in cm

weight

Weight of each patient at study entry, in kg

inherit

Pattern of inheritance (autosomal recessive, X-linked)

steroids

Using corticosteroids at times of study centry(1=Yes, 0=No)

propylac

Using prophylactic antibiotics at time of study entry(1=Yes, 0=No)

hos.cat

A categorization of the hospital region into 4 groups

tstart

Start of each time interval

enum

Sequence number. For each patient, the infection records are in sequnce number order

tstop

End of each time interval

status

Censoring indicator (1=uncensored, 0=censored)

References

Fleming, T. R. and Harrington, D. R. (1991). Counting processes and survival analysis. Wiley: New York.

Therneasu, T. (2012). survival: survival analysis, including penalised likelihood. http://CRAN.Rproject. org/package=survival. R pakcage version 2.36-14.