recrisk.single.ascertain {fam.recrisk}

Familial recurrence risk assuming single proband

Description

Estimate familial recurrence risk, assuming there is a single identified proband in a family

Usage

recrisk.single.ascertain(s, a)

Arguments

s

vector of sizes of families

a

vector of number of affected members

Details

When affected subjects (i.e., probands) attend a clinic independent of their family size and independent of their family history, and if the family history provided by probands is complete (i.e., reporting of family history does not depend on the number of affected members), then we can view the probands and their families as sampled under complete ascertainment. This function estimates the disease recurrence risk when there is a single identified proband per family.

Value

A list with the following values

phat

disease recurrence risk

var.phat

variance of phat

Author(s)

Schaid DJ, Sinnwell JP.

References

Schaid DJ, McDonnell SK, Thibodeau SN. Familial recurrence risk with varying amount of family history. Under review at Genetic Epidemiology, 2018.

Examples

s <- c(4,  8,  6,  6,  10, 8,  7,  8,  5,  6,  10, 4,  4,  8,  6,  8,  4,  5,  9, 
       9,  5,  4,  4,  7,  3,  3,  9,  5,  3,  3,  4,  6,  8,  3,  5,  8,  6,  8, 9,  3)
a <- c(3, 4, 2, 5, 4, 5, 3, 4, 3, 3, 8, 2, 0, 3, 4, 5, 2, 3, 4, 2, 1, 1,
       1, 1, 1, 0, 0, 0, 0, 0, 1, 0, 2, 0, 0, 1, 0, 2, 3, 0)
recrisk.single.ascertain(s,a)