select_boin_mtd {escalation}

Select dose by BOIN's MTD-choosing algorithm.

Description

This method selects dose by the algorithm for identifying the maximum tolerable dose (MTD) described in Yan et al. (2019). This class is intended to be used when a BOIN trial has reached its maximum sample size. Thus, it intends to make the final dose recommendation after the regular BOIN dose selection algorithm, as implemented by get_boin, including any additional behaviours that govern stopping (etc), has gracefully concluded a dose-finding trial. However, the class can be used in any scenario where there is a target toxicity rate. See Examples. Note - this class will not override the parent dose selector when the parent is advocating no dose. Thus this class will not reinstate a dangerous dose.

Usage

select_boin_mtd(
  parent_selector_factory,
  when = c("finally", "always"),
  target = NULL,
  ...
)

Arguments

parent_selector_factory

Object of type selector_factory.

when

Either of: 'finally' to select dose only when the parent dose-selector has finished, by returning continue() == FALSE; or 'always' to use this dose-selection algorithm for every dose decision. As per the authors' original intentions, the default is 'finally'.

target

We seek a dose with this probability of toxicity. If not provided, the value will be sought from the parent dose-selector.

...

Extra args are passed to select.mtd.

Value

an object of type selector_factory.

References

Yan, F., Pan, H., Zhang, L., Liu, S., & Yuan, Y. (2019). BOIN: An R Package for Designing Single-Agent and Drug-Combination Dose-Finding Trials Using Bayesian Optimal Interval Designs. Journal of Statistical Software, 27(November 2017), 0–35. https://doi.org/10.18637/jss.v000.i00

Examples

# This class is intended to make the final dose selection in a BOIN trial:
target <- 0.25
model <- get_boin(num_doses = 5, target = target) %>%
  stop_at_n(n = 12) %>%
  select_boin_mtd()

outcomes <- '1NNN 2NTN 2NNN 3NTT'
model %>% fit(outcomes) %>% recommended_dose()

# However, since behaviour is modular in this package, we can use this method
# to select dose at every dose decision if we wanted:
model2 <- get_boin(num_doses = 5, target = target) %>%
  select_boin_mtd(when = 'always')
model2 %>% fit('1NNT') %>% recommended_dose()
model2 %>% fit('1NNN 2NNT') %>% recommended_dose()

# and with any underlying model:
skeleton <- c(0.05, 0.1, 0.25, 0.4, 0.6)
model3 <- get_dfcrm(skeleton = skeleton, target = target) %>%
  select_boin_mtd(when = 'always')
model3 %>% fit('1NNT') %>% recommended_dose()
model3 %>% fit('1NNN 2NNT') %>% recommended_dose()