R: Required Responders for GO decision RCT

req_resp_rct {earlygating}

R Documentation

Required Responders for GO decision RCT

Description

Function for calculating the minimum required number of responders in the experimental group to make a GO decision in Settings 3 and 4.

Usage

req_resp_rct(
  N_c,
  N_e,
  delta,
  confidence,
  e_a = 0.5,
  e_b = 0.5,
  c_a = 0.5,
  c_b = 0.5,
  h_a = 0.5,
  h_b = 0.5,
  RR_h = NULL,
  N_h = NULL,
  w = NULL,
  plot = T
)

Arguments

`N_c`	Sample Size in the control group.
`N_e`	Sample Size in the experimental group.
`delta`	Required superiority to make a "GO" decision. Corresponds to `\delta`.
`confidence`	Required confidence to make "GO" decision. Corresponds to `\gamma`.
`e_a`	Alpha parameter of Beta Prior Distribution for the experimental response rate. Corresponds to `\alpha_e`. Default is `\frac{1}{2}`.
`e_b`	Beta parameter of Beta Prior Distribution for the experimental response rate. Corresponds to `\beta_e`. Default is `\frac{1}{2}`.
`c_a`	Alpha parameter of Beta Prior Distribution for the control response rate. Corresponds to `\alpha_c`. Default is `\frac{1}{2}`.
`c_b`	Beta parameter of Beta Prior Distribution for the control response rate. Corresponds to `\beta_c`. Default is `\frac{1}{2}`.
`h_a`	Alpha parameter of Beta Prior Distribution for the historical control response rate. Corresponds to `\alpha_h`. Only needs to be specified, if RR_h, N_h and w are also specified. Default is `\frac{1}{2}`.
`h_b`	Beta parameter of Beta Prior Distribution for the historical control response rate. Corresponds to `\beta_h`. Only needs to be specified, if RR_h, N_h and w are also specified. Default is `\frac{1}{2}`.
`RR_h`	Historical control response rate. Corresponds to `p_h`. If specified together with N_h and w, function will use setting 4 from pdf.
`N_h`	Historical control sample size. Corresponds to `n_h`. If specified together with RR_h and w, function will use setting 4 from pdf.
`w`	Level of dynmaic borrowing. Corresponds to `w`.
`plot`	Plots yes or no. Default is TRUE.

Value

Matrix containing pairs of successes in control group and respective required successes in experimental group.

Examples


# Setting 3
req_resp_rct(
  N_c = 25, N_e = 25,
  delta = 0.08, confidence = 0.6
)

# Setting 4
req_resp_rct(
  N_c = 25, N_e = 25,
  delta = 0.08, confidence = 0.6,
  RR_h = 0.5, N_h = 50, w = 0.3
)

[Package earlygating version 1.1 Index]