oc_rct {earlygating} | R Documentation |
RCT Operating Characteristics
Description
Function for calculating the operating characteristics of the RCT Bayesian designs in setting 3 and 4 for early gating.
Usage
oc_rct(
N_c,
N_e,
delta,
delta_power,
confidence,
e_a = 0.5,
e_b = 0.5,
c_a = 0.5,
c_b = 0.5,
h_a = 0.5,
h_b = 0.5,
RR_h = NULL,
N_h = NULL,
w = NULL,
trues = seq(0, 1, 0.01),
plot = T,
legend = T,
legend.pos = "topleft"
)
Arguments
N_c |
Sample Size in the control group. Can be either a single value or a vector, but needs to be the same length as N_e. |
N_e |
Sample Size in the experimental group. Can be either a single value or a vector, but needs to be the same length as N_c. |
delta |
Required superiority to make a "GO" decision. Corresponds to |
delta_power |
Superiority, at which decision power will be evaluated.
Corresponds to |
confidence |
Required confidence to make "GO" decision. Corresponds to |
e_a |
Alpha parameter of Beta Prior Distribution for the experimental response rate.
Corresponds to |
e_b |
Beta parameter of Beta Prior Distribution for the experimental response rate.
Corresponds to |
c_a |
Alpha parameter of Beta Prior Distribution for the control response rate.
Corresponds to |
c_b |
Beta parameter of Beta Prior Distribution for the control response rate.
Corresponds to |
h_a |
Alpha parameter of Beta Prior Distribution for the historical control response rate.
Corresponds to |
h_b |
Beta parameter of Beta Prior Distribution for the historical control response rate.
Corresponds to |
RR_h |
Historical control response rate. Corresponds to |
N_h |
Historical control sample size. Corresponds to |
w |
Level of dynmaic borrowing. Corresponds to |
trues |
Sequence of true control response rates and experimental response rates, at which the Probability to Go will be computed. Default is seq(0,1,0.01) to ensure continuous plots and accurate results. |
plot |
Plots yes or no. Default is TRUE. |
legend |
Logical; whether or not to include legend in plot. Default is TRUE. |
legend.pos |
Position of legend. Default is "topleft". |
Value
A matrix containing the decision power and decision alpha with respect to the true control response rate.
Examples
# Setting 3
oc_rct(
N_c = 25, N_e = 25, delta = 0.08,
delta_power = 0.13, confidence = 0.6
)
# Setting 4
oc_rct(
N_c = 25, N_e = 25, delta = 0.08,
delta_power = 0.13, confidence = 0.6,
RR_h = 0.5, N_h = 50, w = 0.3
)