stop_for_consensus_reached {dtpcrm}

Stopping for consensus

Description

This is a function for use with applied_crm for the stop_func argument. The rule will suggest stopping in the scenario that a particular number of patients has already been treated at the current recommended MTD.

Usage

stop_for_consensus_reached(x, req_at_mtd)

Arguments

x

An object of class 'mtd'.

req_at_mtd

An integer; the number of patients required at current estimate of MTD to suggest stopping for consensus.

Details

This function is an example of a possible stopping function to be used with applied_crm, it will modifiy the 'mtd' class object produced by applied_crm to include a logical value under the name 'stop' indicting whether or not the trial should stop. The package dtpcrm contains a few of these functions for possible use with applied_crm.

Examples

prior  <- c(0.1, 0.3, 0.5)
target <- 0.2
tox    <- c(0, 0, 1, 0, 1, 1)
level  <- c(1, 1, 1, 2, 2, 2)

stop_rule <- function(x){
  x <- stop_for_consensus_reached(x, req_at_mtd = 6)
}

crm <- applied_crm(prior, target, tox, level, no_skip_esc = TRUE, no_skip_deesc = TRUE,
                   global_coherent_esc = TRUE, stop_func = stop_rule)