helper_TS {dtComb}

Helper function for TS method.

Description

The helper_TS function calculates the combination coefficient and optimized value of given biomarkers for the TS method.

Usage

helper_TS(theta, markers, status)

Arguments

theta

a numeric parameter that will be estimated in TS method for the combination score

markers

a numeric data frame that contains the biomarkers

status

a factor data frame that includes the actual disease status of the patients

Value

A numeric Optimized value calculated with combination scores using theta

Author(s)

Serra Ilayda Yerlitas, Serra Bersan Gengec, Necla Kochan, Gozde Erturk Zararsiz, Selcuk Korkmaz, Gokmen Zararsiz

Examples

# call data
data(exampleData1)

# define the function parameters
markers <- cbind(exampleData1$ddimer, exampleData1$log_leukocyte)
status <- factor(exampleData1$group, levels = c("not_needed", "needed"))

t <- 0.5

stat <- helper_TS(theta = t, markers = markers, status = status)