helper_PCL {dtComb}

Helper function for PCL method.

Description

The helper_PCL function estimates the optimized value of given biomarkers for the PCL method.

Usage

helper_PCL(lambda, neg.set, pos.set)

Arguments

lambda

a numeric parameter that will be estimated in minmax method for the combination score

neg.set

a numeric data frame that contains the observation with negative status

pos.set

a numeric data frame that contains the observation with positive status

Value

A numeric value for the estimated optimized value

Author(s)

Serra Ilayda Yerlitas, Serra Bersan Gengec, Necla Kochan, Gozde Erturk Zararsiz, Selcuk Korkmaz, Gokmen Zararsiz

Examples

# call data
data(exampleData1)

# define the function parameters
markers <- cbind(exampleData1$ddimer, exampleData1$log_leukocyte)
status <- factor(exampleData1$group, levels = c("not_needed", "needed"))

neg.set <- markers[status == levels(status)[1], ]
pos.set <- markers[status == levels(status)[2], ]

lambda <- 0.5

stat <- helper_PCL(lambda, neg.set = neg.set, pos.set = pos.set)