dip8 {disprofas} | R Documentation |
Parameter estimates of Weibull fit to individual dissolution profiles
Description
A data set containing the Weibull parameter estimates obtained from fitting
Weibull curves to the cumulative dissolution profiles of individual
tablets of one reference batch and one test or post-change batch with a
minor modification and a second test or post-change batch with a major
modification, tablets each.
Usage
data(dip8)
Format
A data frame with 36 observations and 4 variables:
- tablet
Factor with levels
1
to12
representing individual tablets- type
Factor with levels
ref
(Reference),minor
(Test) andmajor
(Test)- alpha
Weibull parameter
, i.e. the scale parameter being a function of the undissolved proportion at
- beta
Weibull parameter
, i.e. the shape parameter which is related to the dissolution rate per unit of time
Source
See reference: Example data set shown in Table III.
References
Sathe, P.M., Tsong, Y., and Shah, V.P. In-Vitro dissolution profile
comparison: Statistics and analysis, model dependent approach.
Pharm Res. 1996; 13(12): 1799-1803.
doi:10.1023/a:1016020822093
Examples
str(dip8)