dip7 {disprofas}

Parameter estimates of Weibull fit to individual dissolution profiles

Description

A data set containing the Weibull parameter estimates obtained from fitting Weibull curves to the cumulative dissolution profiles of individual tablets of three reference batches and one test batch, n = 12 tablets each. The Weibull curve is fitted according to the formula x(t) = x_{max} ( 1 - exp(- \alpha t^{\beta})), where x(t) is the percent released at time t divided by 100, x_{max} is the maximal release (set to be 100, i.e. assumed to be a constant).

Usage

data(dip7)

Format

A data frame with 48 observations and 5 variables:

tablet

Factor with levels 1 to 12 representing individual tablets

batch

Factor with levels b0, b1, b2, b3 and b4

type

Factor with levels ref (Reference) and test (Test)

alpha

Weibull parameter \alpha, i.e. the scale parameter being a function of the undissolved proportion at t = 1

beta

Weibull parameter \beta, i.e. the shape parameter which is related to the dissolution rate per unit of time

Source

See reference: Example data set shown in Table 4.

References

Tsong, Y., Hammerstrom, T., Chen, J.J. Multipoint dissolution specification and acceptance sampling rule based on profile modeling and principal component analysis. J Biopharm Stat. 1997; 7(3): 423-439.
doi:10.1080/10543409708835198

Examples

str(dip7)