dip7 {disprofas} | R Documentation |
Parameter estimates of Weibull fit to individual dissolution profiles
Description
A data set containing the Weibull parameter estimates obtained from fitting
Weibull curves to the cumulative dissolution profiles of individual
tablets of three reference batches and one test batch,
tablets each. The Weibull curve is fitted according to the formula
, where
is
the percent released at time
divided by
,
is the maximal release (set to be
, i.e. assumed to be a
constant).
Usage
data(dip7)
Format
A data frame with 48 observations and 5 variables:
- tablet
Factor with levels
1
to12
representing individual tablets- batch
Factor with levels
b0
,b1
,b2
,b3
andb4
- type
Factor with levels
ref
(Reference) andtest
(Test)- alpha
Weibull parameter
, i.e. the scale parameter being a function of the undissolved proportion at
- beta
Weibull parameter
, i.e. the shape parameter which is related to the dissolution rate per unit of time
Source
See reference: Example data set shown in Table 4.
References
Tsong, Y., Hammerstrom, T., Chen, J.J. Multipoint dissolution specification
and acceptance sampling rule based on profile modeling and principal
component analysis. J Biopharm Stat. 1997; 7(3): 423-439.
doi:10.1080/10543409708835198
Examples
str(dip7)