R: Choice of the next given dose level.

doseChoice {dfped}

R Documentation

Choice of the next given dose level.

Description

Algorithm giving the next dose which is the safe most successful dose (sMSD).

Usage

doseChoice(probaTox, probaEff, p, targetTox, givenDose)

Arguments

`probaTox`	The probability of toxicity estimated with STAN model.
`probaEff`	The probability of efficacy estimated with STAN model.
`p`	The probability of success.
`targetTox`	The target of toxicity.
`givenDose`	The vector of doses given to patients so far.

Author(s)

Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr

References

Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.

Examples

r <- 0.10
q <- 0.17
p <- 0.9
targetTox <- 0.6 
givenDose <- 2
newDose <- doseChoice(r, q, p, targetTox, givenDose)   
newDose

[Package dfped version 1.1 Index]