| concAd {dfped} | R Documentation |
Concentration of a specific molecule in plasma for the adult population.
Description
Compute the concentration of a specific molecule in plasma for the adult population according to the percentage binding with albumin and alpha1-acid glycoprotein.
Usage
concAd(percAlb, percAlpha1AG)
Arguments
percAlb |
Percentage of the molecule binding with albumin. |
percAlpha1AG |
Percentage of the molecule binding with alpha1-acid glycoprotein. |
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.
See Also
Examples
perc_alb <- 1
perc_alpha1AG <- 0
concAd(perc_alb, perc_alpha1AG)