concAd {dfped}R Documentation

Concentration of a specific molecule in plasma for the adult population.

Description

Compute the concentration of a specific molecule in plasma for the adult population according to the percentage binding with albumin and alpha1-acid glycoprotein.

Usage

concAd(percAlb, percAlpha1AG)

Arguments

percAlb

Percentage of the molecule binding with albumin.

percAlpha1AG

Percentage of the molecule binding with alpha1-acid glycoprotein.

Author(s)

Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr

References

Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.

Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.

See Also

concCh

Examples

perc_alb <- 1
perc_alpha1AG <- 0 
concAd(perc_alb, perc_alpha1AG) 

[Package dfped version 1.1 Index]