| KCYP2C8 {dfped} | R Documentation |
Fraction of adult CYP2C8 abundance according to age.
Description
Compute the value of the fraction of adult CYP2C8 abundance according to the children age. It is described by a hyperbolic function.
Usage
KCYP2C8(age)
Arguments
age |
The age of children. |
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.
See Also
KCYP1A2, KCYP2B6, KCYP2C9, KCYP2C18_19, KCYP2D6, KCYP2E1,
KCYP3A4_5, KCYP3A
Examples
age <- 2
KCYP2C8(age)