KCYP2C8 {dfped}R Documentation

Fraction of adult CYP2C8 abundance according to age.

Description

Compute the value of the fraction of adult CYP2C8 abundance according to the children age. It is described by a hyperbolic function.

Usage

KCYP2C8(age) 

Arguments

age

The age of children.

Author(s)

Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr

References

Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.

Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.

See Also

KCYP1A2, KCYP2B6, KCYP2C9, KCYP2C18_19, KCYP2D6, KCYP2E1, KCYP3A4_5, KCYP3A

Examples

age <- 2
KCYP2C8(age)

[Package dfped version 1.1 Index]