| Cladu {dfped} | R Documentation |
Clearance of the unbound fraction of a specific molecule for the adult population.
Description
Compute the clearance of the unbound fraction of a specific molecule for the adult population.
Usage
Cladu(Clad, fuAd, Fad)
Arguments
Clad |
The apparent clearance for adults. |
fuAd |
Unbound bioavailability for adults for the molecule. |
Fad |
Bioavailability for adults. |
Author(s)
Artemis Toumazi artemis.toumazi@gmail.com, Caroline Petit caroline.petit@crc.jussieu.fr, Sarah Zohar sarah.zohar@inserm.fr
References
Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.
See Also
Examples
Cl_ad <- 3.95
F_ad <- 0.6
fu_ad <- 1
Cladu(Cl_ad, fu_ad, F_ad)
[Package dfped version 1.1 Index]