dfcomb-package {dfcomb}

Phase I/II Adaptive Dose-Finding Design for Combination Studies

Description

Phase I/II adaptive dose-finding design for combination studies where toxicity rates are supposed to increase with both agents.

Details

The DESCRIPTION file:

Package:	dfcomb
Type:	Package
Title:	Phase I/II Adaptive Dose-Finding Design for Combination Studies
Version:	3.1-1
Date:	2022-12-26
Author:	Marie-Karelle Riviere and Jacques-Henri Jourdan
Maintainer:	Jacques-Henri Jourdan <[e-mail]>
Copyright:	src/arms.c and src/arms.h are copyright Wally Gilks. All other files are copyright Sanofi-Aventis R&D, Institut de Recherches Internationales Servier and Institut national de la sante et de la recherche medicale.
Description:	Phase I/II adaptive dose-finding design for combination studies where toxicity rates are supposed to increase with both agents.
License:	GPL-3
Depends:	R (>= 3.2.3)
LinkingTo:	BH (>= 1.55), Rcpp, RcppProgress (>= 0.2.1)
NeedsCompilation:	yes

Index of help topics:

CombIncrease_next       Combination determination with logistic model
CombIncrease_sim        Combination design Simulator using Logistic
                        model
dfcomb-package          Phase I/II Adaptive Dose-Finding Design for
                        Combination Studies

Author(s)

Marie-Karelle Riviere and Jacques-Henri Jourdan

Maintainer: Jacques-Henri Jourdan <[e-mail]>

References

Riviere MK, Yuan Y, Dubois F, Zohar S (2014). A Bayesian dose-finding design for drug combination clinical trials based on the logistic model. Pharm Stat, 13, 4:247-57.