awot_null {cwot}

Prepare null model for awot.

Description

Prepare null model for awot.

Usage

awot_null(y, tr, x = NULL)

Arguments

y

- Continuous response variable.

tr

- Binary treatment variable, 1 for treated, 0 for placebo.

x

- Covariates in addition to treatment variable.

Value

A list of objects needed for awot.

References

Hong Zhang, Devan Mehrotra and Judong Shen, "AWOT and CWOT for Genotype and Genotype by Treatment Interaction Joint Analysis in Pharmacogenetics GWAS".

Examples

n = 100
y = rnorm(n)
x = data.frame(x1=rnorm(n))
tr = rbinom(n, 1, 0.5)
nullmod = awot_null(y, tr, x)