GUTS_RED_IT {cvasi}

GUTS-RED-IT scenario

Description

Reduced General Unified Threshold models of Survival (GUTS) with individual tolerance (IT).

Usage

GUTS_RED_IT(param, init)

Arguments

param

optional named list or vector with model parameters

init

optional named numeric vector to use as initial state

Value

an S4 object of type GutsRedIt

State variables

The following list describes the default names and standard units of GUTS-RED state variables:

• D, scaled damage (conc)

• H, cumulative hazard (-)

The state variables are initialized with zero by default.

IT model parameters

• kd, dominant rate constant (time^-1)

• hb, background hazard rate (time^-1)

• alpha, median of thresholds (conc)

• beta, shape parameter (-)

Effects

The effect endpoint L (lethality) is available for GUTS-RED models. A value of zero (0.0) denotes no effect on organism survival. A value of one (1.0) denotes a lethality rate of 100%, i.e. no survivors.

In addition, the surival rate over time can be derived for all output time points using survival().

References

EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues), Ockleford C, Adriaanse P, Berny P, et al., 2018: Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms. EFSA Journal 2018; 16(8):5377, 188 pp. doi:10.2903/j.efsa.2018.5377

See Also

Other GUTS-RED models: GUTS-RED-models, GUTS_RED_SD()