pbc2 {cvGEE}

Mayo Clinic Primary Biliary Cirrhosis Data

Description

Followup of 312 randomised patients with primary biliary cirrhosis, a rare autoimmune liver disease, at Mayo Clinic.

Format

A data frame with 1945 observations on the following 20 variables.

id

patients identifier; in total there are 312 patients.

years

number of years between registration and the earlier of death, transplantion, or study analysis time.

status

a factor with levels alive, transplanted and dead.

drug

a factor with levels placebo and D-penicil.

age

at registration in years.

sex

a factor with levels male and female.

year

number of years between enrollment and this visit date, remaining values on the line of data refer to this visit.

ascites

a factor with levels No and Yes.

hepatomegaly

a factor with levels No and Yes.

spiders

a factor with levels No and Yes.

edema

a factor with levels No edema (i.e., no edema and no diuretic therapy for edema), edema no diuretics (i.e., edema present without diuretics, or edema resolved by diuretics), and edema despite diuretics (i.e., edema despite diuretic therapy).

serBilir

serum bilirubin in mg/dl.

serChol

serum cholesterol in mg/dl.

albumin

albumin in gm/dl.

alkaline

alkaline phosphatase in U/liter.

SGOT

SGOT in U/ml.

platelets

platelets per cubic ml / 1000.

prothrombin

prothrombin time in seconds.

histologic

histologic stage of disease.

status2

a numeric vector with the value 1 denoting if the patient was dead, and 0 if the patient was alive or transplanted.

Note

The data frame pbc2.id contains the first measurement for each patient. This data frame is used to fit the survival model.

References

Fleming, T. and Harrington, D. (1991) Counting Processes and Survival Analysis. Wiley, New York.

Therneau, T. and Grambsch, P. (2000) Modeling Survival Data: Extending the Cox Model. Springer-Verlag, New York.