clfs.pest {currentSurvival}

Estimates Current Leukaemia-Free Survival (CLFS) Function

Description

This is an internal function and is not usually called by user.
This function estimates the current leukaemia-free survival (CLFS) function, i.e. the probability that a patient is alive and in any disease remission after achieving the first disease remission. Only patients who achieved at least one disease remission during their treatment course are used for the estimation of the CLFS function.

Usage

clfs.pest(E, LastContact, Exitus, maxx)

Arguments

E

a matrix with ascending times from achievement of the first disease remission to occurrence of individual events (in days); the size of the data matrix is n times (2*r-1), where n is the number of patients and r is the maximum number of disease remissions achieved by patients; the data matrix consists of the following columns:
E[,1] is the time from achievement of the first disease remission to loss of the first disease remission
E[,2] is the time from achievement of the first disease remission to achievement of the second disease remission
E[,3] is the time from achievement of the first disease remission to loss of the second disease remission
...
E[,2*r-2] is the time from achievement of the first disease remission to achievement of the rth disease remission
E[,2*r-1] is the time from achievement of the first disease remission to loss of the rth disease remission

LastContact

a vector containing the follow-up time (time from achievement of the first disease remission to death or to the date of last contact with a patient)

Exitus

a vector containing the censoring indicators (1..patient died, 0..patient is censored)

maxx

maximum follow-up time in days

Value

a list containing the following elements:

x

days from 0 to maximum follow-up time maxx

y

CLFS function estimates at each day

Author(s)

Eva Janousova, Tomas Pavlik
Institute of Biostatistics and Analyses
Masaryk University, Brno, Czech Republic
[e-mail]

References

Pavlik T., Janousova E., Pospisil Z., et al. (2011). Estimation of current cumulative incidence of leukaemia-free patients and current leukaemia-free survival in chronic myeloid leukaemia in the era of modern pharmacotherapy. BMC Med Res Methodol 11:140.

See Also

clfs

Examples

# This is an internal function and is not usually called by user.