StoppingTargetBiomarker-class {crmPack} | R Documentation |
Stop based on probability of target biomarker
Description
Stop based on probability of target biomarker
Slots
target
the biomarker target range, that needs to be reached. For example, (0.8, 1.0) and
scale="relative"
means we target a dose with at least 80% of maximum biomarker level.scale
either
relative
(default, then thetarget
is interpreted relative to the maximum, so must be a probability range) orabsolute
(then thetarget
is interpreted as absolute biomarker range)prob
required target probability for reaching sufficient precision
Examples
# As example, here is the rule for:
# stopping the study if there is at least 0.5 probability that the biomarker
# (efficacy) is within the biomarker target range of [0.9, 1.0] (relative to the
# maximum for the biomarker).
myStopping <- StoppingTargetBiomarker(target = c(0.9, 1),
prob = 0.5)
[Package crmPack version 1.0.6 Index]