StoppingMTDdistribution-class {crmPack}

Stop based on MTD distribution

Description

Has 90% probability above a threshold of 50% of the current MTD been reached? This class is used for this question.

Slots

target

the target toxicity probability (e.g. 0.33) defining the MTD

thresh

the threshold relative to the MTD (e.g. 0.5)

prob

required probability (e.g. 0.9)

Examples

# As example, here is the rule for: 
#   stopping the study if there is at least 0.9 probability that MTD > 0.5*next_dose.
#   Here MTD is defined as the dose for which prob(DLE)=0.33

myStopping <- StoppingMTDdistribution(target = 0.33,
                                      thresh = 0.5,
                                      prob = 0.9)