LogisticKadane-class {crmPack} | R Documentation |
Reparametrized logistic model
Description
This is the logistic model in the parametrization of Kadane et al. (1980).
Details
Let be the probability of a DLT and the minimum
dose
, and let
be the dose with target toxicity
probability
, i.e.
. Then it can easily
be shown that the logistic regression model has intercept
and slope
The prior is a uniform distribution for between
and
, and for
as well a uniform distribution
between
and
.
The slots of this class, required for creating the model, are the target toxicity, as well as the minimum and maximum of the dose range. Note that these can be different from the minimum and maximum of the dose grid in the data later on.
Slots
theta
the target toxicity probability
xmin
the minimum of the dose range
xmax
the maximum of the dose range
Examples
model <- LogisticKadane(theta = 0.33,
xmin = 1,
xmax = 200)
[Package crmPack version 1.0.6 Index]