IncrementsRelativeDLT-class {crmPack}

Increments control based on relative differences in terms of DLTs

Description

Note that DLTintervals is to be read as follows. If for example, we want to specify three intervals: First 0 DLTs, second 1 or 2 DLTs, and third at least 3 DLTs, then we specify DLTintervals to be c(0, 1, 3). That means, the right bound of the intervals are exclusive to the interval – the vector only gives the left bounds of the intervals. The last interval goes from 3 to infinity.

Slots

DLTintervals

an integer vector with the left bounds of the relevant DLT intervals

increments

a vector of the same length with the maximum allowable relative increments in the DLTintervals

Examples

# As example, here is the rule for: 
#      maximum doubling the dose if no DLTs were observed at the current dose
#      or maximum increasing the dose by 1.33 if 1 or 2 DLTs were observed at the current dose
#      or maximum increasing the dose by 1.22 if 3 or more DLTs were observed

myIncrements <- IncrementsRelativeDLT(DLTintervals = c(0, 1, 3),
                                      increments = c(1, 0.33, 0.2))