DualEndpointEmax-class {crmPack} | R Documentation |
Dual endpoint model with emax function for dose-biomarker relationship
Description
This class extends the DualEndpoint
class. Here the
dose-biomarker relationship is modelled by a parametric EMAX function:
Details
where is a reference dose,
and
are the
minimum and maximum levels for the biomarker and
is the dose
achieving half of the maximum effect
.
All parameters can currently be assigned uniform distributions or be fixed in advance.
Slots
E0
either a fixed number or the two uniform distribution parameters
Emax
either a fixed number or the two uniform distribution parameters
ED50
either a fixed number or the two uniform distribution parameters
refDoseEmax
the reference dose
Examples
model <- DualEndpointEmax(E0 = c(0, 100),
Emax = c(0, 500),
ED50 = c(10,200),
refDoseEmax = 1000,
mu = c(0, 1),
Sigma = matrix(c(1, 0, 0, 1), nrow=2),
sigma2W = c(a=0.1, b=0.1),
rho = c(a=1, b=1))
[Package crmPack version 1.0.6 Index]