Phase I/II CRM Based Drug Combination Design

---

Documentation for package ‘crm12Comb’ version 0.1.3

• DESCRIPTION file.
• User guides, package vignettes and other documentation.

Help Pages

dat	Output dataset for examples given list of inputs.
doseComb_to_mat	Title: Get 6 complete orderings for toxicity and efficacy for drug combinations
efficacy_est	Efficacy estimation
empiric_GammaPriorLikelihood	empiric model with gamma prior
empiric_NormalPriorLikelihood	empiric model with normal prior
enroll_patient_plot	Plot patient enrollment for single trial
get_ordering	Complete orderings for combinations of two drugs
logisticOnePara_GammaPriorLikelihood	one-parameter logistic model with gamma prior
logisticOnePara_NormalPriorLikelihood	one-parameter logistic model with normal prior
logisticTwoPara_GammaPriorLikelihood	two-parameter logistic model with gamma prior
logisticTwoPara_NormalPriorLikelihood	two-parameter logistic model with normal prior
maximization_phase	Maximization phase
ODC_plot	Plot optimal combination dose selections
patient_allocation_plot	Plot patient allocation for a single trial
priorSkeletons	Generate the skeletons of toxicity and efficacy
randomization_phase	Adaptive randomization
rBin2Corr	Generate correlated binary variables
sample_plot	Sample plot for a given output results
SIM_phase_I_II	Single simulation of phase I/II adaptive design for drug combinations based on CRM design
tanh_ExpPriorLikelihood	Title: Bayesian likelihood inference
toxicity_est	Toxicity estimation