vardiffC {compareC} | R Documentation |
This is a function used to estimate the variance of the difference between two correlated overall C indices
vardiffC(timeX, statusX, scoreY, scoreZ)
timeX |
The vector of actual survival time X, one survival time for each observation |
statusX |
The matching vector of event indicator for time X, 1 if occured and 0 otherwise |
scoreY |
The vector of the first measured biomarker Y, one for each of the same observations, based on which the variance of the difference in overall C indices is to be estimated |
scoreZ |
The vector of the second measured biomarker Z, one for each of the same observations, based on which the variance of the difference in overall C indices is to be estimated |
est.vardiff_c |
The estimated variance of the difference of two C indices |
est.varCxy |
The estimated variance of the C index for scoreY |
est.varCxz |
The estimated variance of the C index for scoreZ |
est.cov |
The estimated covariance between the two C indices for scoreY and that for scoreZ |
Le Kang, Weijie Chen
Harrell FE, Califf RM, Pryor DB, Lee KL, and Rosati RA. (1982) Evaluating the yield of medical tests. The Journal of the American Medical Association, 247(18), 2543–2546
Pencina MJ and D'Agostino RB. (2004) Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation. Statistics in Medicine, 23(13), 2109–2123
Kang L, Chen W, Petrick NA, and Gallas BD. (2014) Comparing two correlated C indices with right-censored survival outcome: a one-shot nonparametric approach. Statistics in Medicine, 34(4), 685–703, doi: 10.1002/sim.6370
demo(testC)