apri {cliot}

Calculate APRI (AST to Platelet Ratio)

Description

Using aspartate aminotransferase and platelet values, calculate the APRI index, devised by Wait et al 2003, estimates hepatic fibrosis and cirrhosis in patients with hepatitis C. APRI value <0.7 is indicative of little to no evidence of fibrosis, 0.7-1.0 is moderate fibrosis, and 1.0+ is evidence of cirrhosis and significant fibrosis, as validated by Khan et al. 2008 and Lin et al 2011.

Usage

apri(ast, plt)

Arguments

ast

Numeric value of aspartate aminotransferase in U/L.

plt

Numeric value of platelets in 10^3/uL or 10^9/L.

Value

A numeric value/vector with predicted APRI index score.

References

Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38(2):518-526. doi:10.1053/jhep.2003.50346 Khan DA, Fatima-Tuz-Zuhra, Khan FA, Mubarak A. Evaluation of diagnostic accuracy of APRI for prediction of fibrosis in hepatitis C patients. J Ayub Med Coll Abbottabad. 2008;20(4):122-126. Lin, Z.-H., Xin, Y.-N., Dong, Q.-J., Wang, Q., Jiang, X.-J., Zhan, S.-H., Sun, Y. and Xuan, S.-Y. (2011), Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis: An updated meta-analysis. Hepatology, 53: 726-736. https://doi.org/10.1002/hep.24105

Examples

# The function is defined as
apri(16,150)