lu2004 {care}

Brain Aging Study of Lu et al. (2004)

Description

Gene expression data (403 genes for 30 samples) from the microarray study of Lu et al. (2004).

Usage

data(lu2004)

Format

lu2004$x is a 30 x 403 matrix containing the log expression levels. The rows contain the samples and the columns the genes.

lu2004$y is the age of for each sample.

Details

This data set contains measurements of the gene expression of 403 genes from 30 human brain samples. In addition, the age of each patient is provided.

Source

The original data are available from the GEO public functional genomics database at URL https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE1572 and are described in Lu et al. (2004). The selected 403 genes result from prescreening and preprocessing as described in Zuber and Strimmer (2011).

References

Lu, T., et al. 2004. Gene regulation and DNA damage in the ageing human brain. Nature 429:883–891. <DOI:10.1038/nature02661>

Zuber, V., and K. Strimmer. 2011. High-dimensional regression and variable selection using CAR scores. Statist. Appl. Genet. Mol. Biol. 10: 34. <DOI:10.2202/1544-6115.1730>

Examples

# load care library
library("care")

# load Lu et al. (2004) data set
data(lu2004)
dim(lu2004$x) # 30 403
hist(lu2004$x)
length(lu2004$y) # 30
lu2004$y # age