model_library {campsismod}

R Documentation

CAMPSIS model library.

Description

A list containing pharmacokinetic (PK) and pharmacodynamic (PD) model templates.

Usage

model_library

Format

A list with all the models:

advan1_trans1

1-compartment PK model (K,V)

advan1_trans2

1-compartment PK model (CL,V)

advan2_trans1

1-compartment PK model with absorption compartment (KA,K,V)

advan2_trans2

1-compartment PK model with absorption compartment (KA,CL,V)

advan3_trans1

2-compartment PK model (K,V,K12,K21)

advan3_trans3

2-compartment PK model (CL,V,Q,VSS)

advan3_trans4

2-compartment PK model (CL,V1,V2,Q)

advan4_trans1

2-compartment PK model with absorption compartment (KA,K,V,K12,K21)

advan4_trans3

2-compartment PK model with absorption compartment (KA,CL,V,Q,VSS)

advan4_trans4

2-compartment PK model with absorption compartment (KA,CL,V1,V2,Q)

advan11_trans4

3-compartment PK model (CL,V1,V2,V3,Q2,Q3)

advan12_trans4

3-compartment PK model with absorption compartment (KA,CL,V1,V2,V3,Q2,Q3)

direct_effect_model

direct effect PD model (EMAX,EC50,GAMMA,E0)

effect_cmt_model

effect compartment PD model (KE0)

irm_kin_inhibition

indirect response PD model - inhibition of KIN (IC50,KIN,KOUT)

irm_kin_stimulation

indirect response PD model - stimulation of KIN (EMAX,EC50,KIN,KOUT)

irm_kout_inhibition

indirect response PD model - inhibition of KOUT (IC50,KIN,KOUT)

irm_kout_stimulation

indirect response PD model - stimulation of KOUT (EMAX,EC50,KIN,KOUT)

transit_cmt_model

transit compartment PD model (BASE,POWER,MTT,SLOPE,KTR)

filgrastim_pkpd_krzyzanski

PK/PD model of filgrastim (Krzyzanski et al., see URL below)

my_model1

Example of 2-compartment PK model with variance-covariance matrix

Source

https://www.iconplc.com/solutions/technologies/nonmem/

http://repository.ddmore.eu/model/DDMODEL00000077/

https://calvagone.github.io/campsis.doc/

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