brk_toxFun {briskaR}R Documentation

Functions for Toxicokinetic-Toxidynamic (TKTD) models

Description

Functions for Toxicokinetic-Toxidynamic (TKTD) models

ODE solver applied to IT-GUTS model

ODE solver applied to SD-GUTS model

Usage

brk_toxFun_damage1(exposure, kin, kout)

brk_toxFun_survival1(damage, alpha1, alpha2, alpha3)

brk_toxFun_survival2(damage, LC50, slope)

brk_survIT(time, Cw, listParameters)

brk_survSD(time, Cw, listParameters)

Arguments

exposure

exposure level of individual

kin

parameter describing the intake rate of the element

kout

parameter describing the excretion rate of the element

damage

damage level on which the survival model is going to be applied

alpha1

parameter describing the natural background death mortality rate

alpha2

parameter describing the killing rate of the element on individual

alpha3

exponential parameter describing the killing rate of the element on individual

LC50

parameter describing the lethal concentration for 50% of the population

slope

parameter describing the slope of the curve

time

vector of time of the exposure profile

Cw

vector of concentration of the exposure profile

listParameters

A list of parameter for the SD model


[Package briskaR version 1.0.3 Index]