invertBRAIDrsm {braidrm}

Invert BRAID Response Function

Description

Determines which drug concentrations, when paired with the given input concentrations, produce the given response values. Useful for estimating potentiation of one compound by presence of the other.

Usage

invertBRAIDrsm(val, DA=NULL, DB=NULL, parv)

Arguments

val

Effect value or values to be inverted. If a single value, it will be repeated for all values of DA or DB which are input.

DA

Concentrations of drug A to be inverted. If NULL (the default), the concentrations in DB will be inverted and the concentrations of drug A will be estimated.

DB

Concentrations of drug B to be inverted. If NULL (the default), the concentrations in DA will be inverted and the concentrations of drug B will be estimated.

parv

10-element vector specifying the full set of parameters for the BRAID surface

Value

A vector of concentrations which, when paired with the given concentrations, produce the given values. If DA is NULL, the vector contains the concentrations of drug A corresponding to the concentrations of drug B given in DB. If concB is null, the vector contains the concentrations of drug B corresponding to the concentrations of drug A give in DA. Exactly one of these two inputs must be NULL.

Author(s)

Nathaniel R. Twarog

See Also

braidrm, evalBRAIDrsm

Examples

level <- 90
doses <- c(0,10^-8,10^-7,10^-6)
ec90A <- invertBRAIDrsm(level,DB=doses,parv=c(10^-6,10^-6,1.5,1.5,1,1.8,0,100,100,100))