braidrm-package {braidrm}

Fitting Dose Response with the BRAID Combined Action Model

Description

This package provides functions necessary for evaluating, analyzing, and fitting combined action dose response surfaces with the Bivariate Response to Additive Interacting Dose (BRAID) model of combined action.

Details

Package:	braidrm
Type:	Package
Version:	0.66
Date:	2016-01-26
License:	GPL (>= 3)

A mathematical description of the BRAID surface model can be found in evalBRAIDrsm. The heart of the package is the function braidrm, which takes a set of paired concentrations and measured responses and fits a particular instantiation of the BRAID model to the data. Bootstrapped confidence intervals on all fit parameters can be constructed by braidrm, or afterwards by the function getBRAIDbootstrap. Known BRAID surfaces can be evaluated or inverted using the calculating functions evalBRAIDrsm and invertBRAIDrsm. As analysis of combined dose response is closely linked to single agent dose response, we have provided several simple functions for analyzing such relationships, such as findBestHill. Finally, we also provide the more complete analytic functions findBestBRAID and runBRAIDanalysis, which perform a series of BRAID surface fits (and in the case of runBRAIDanalysis, single agent fits) to simplify the process of implementing a BRAID analysis pipeline.

Author(s)

Nathaniel R. Twarog <[e-mail]>