interval_posterior_nominator {bpp} | R Documentation |
If we update the prior with the knowledge that the interim estimate was between a futility and efficacy boundary at an interim analysis, we get a density that is proportional to the value of this function.
interval_posterior_nominator(x, prior = c("normal", "flat"),
IntEffBoundary, IntFutBoundary, interimSE, priormean, ...)
x |
Value at which to evaluate the function. |
prior |
Prior density on effect sizes. |
IntEffBoundary |
Efficacy boundary at the interim analysis. |
IntFutBoundary |
Futility boundary at the interim analysis. |
interimSE |
(Known) standard error of |
priormean |
Prior mean. |
... |
Further arguments specific to the chosen prior (see |
Value of the function, a real number.
Kaspar Rufibach (maintainer)
kaspar.rufibach@roche.com
Rufibach, K., Jordan, P., Abt, M. (2016a). Sequentially Updating the Likelihood of Success of a Phase 3 Pivotal Time-to-Event Trial based on Interim Analyses or External Information. J. Biopharm. Stat., 26(2), 191–201.
# type ?bpp_1interim for code of all the computations in Rufibach et al (2016a).