bpp {bpp} | R Documentation |
Compute BPP for a Normally distributed endpoint, e.g. log(hazard ratio).
bpp(prior = c("normal", "flat"), successmean, finalSE, priormean, ...)
prior |
Prior density on effect sizes. |
successmean |
The mean that defines success at the final analysis. Typically chosen to be the minimal detectable difference, i.e. the critical on the scale of the effect size of interest corresponding to the significance level at the final analysis. |
finalSE |
(Known) standard error at which the final analysis of the study under consideration takes place. |
priormean |
Prior mean. |
... |
Further arguments specific to the chosen prior (see |
A real number, the bpp.
Kaspar Rufibach (maintainer)
kaspar.rufibach@roche.com
Rufibach, K., Jordan, P., Abt, M. (2016a). Sequentially Updating the Likelihood of Success of a Phase 3 Pivotal Time-to-Event Trial based on Interim Analyses or External Information. J. Biopharm. Stat., 26(2), 191–201.
Rufibach, K., Burger, H.U., Abt, M. (2016b). Bayesian Predictive Power: Choice of Prior and some Recommendations for its Use as Probability of Success in Drug Development. Pharm. Stat., 15, 438–446.
# type ?bpp_1interim for code of all the computations in Rufibach et al (2016a).