toer {blindrecalc}

Type I Error Rate

Description

Computes the type I error rate of designs with blinded sample size recalculation or of fixed designs for one or several values of the nuisance parameter.

Usage

toer(design, n1, nuisance, recalculation, ...)

Arguments

design

object of class TestStatistic created by setup

n1

total number of patients that are recruited before the sample size is recalculated

nuisance

nuisance parameter that is estimated at the interim analysis

recalculation

Should the sample size be recalculated after n1 n1 patients are recruited?

...

Further optional arguments.

Details

The method is only vectorized in either nuisance or n1.

The method is implemented for the classes Student, ChiSquare, and FarringtonManning.

Value

One type I error rate value for every nuisance parameter and every value of n1.

Examples

d <- setupStudent(alpha = .025, beta = .2, r = 1, delta = 3.5, delta_NI = 0,
                  alternative = "greater", n_max = 156)
toer(d, n1 = 20, nuisance = 5.5, recalculation = TRUE)