toer,Student-method {blindrecalc}

Type I Error Rate

Description

Computes the type I error rate of designs with blinded sample size recalculation or of fixed designs for one or several values of the nuisance parameter.

Usage

## S4 method for signature 'Student'
toer(
  design,
  n1,
  nuisance,
  recalculation = TRUE,
  iters = 10000,
  seed = NULL,
  allocation = c("approximate", "exact"),
  ...
)

Arguments

design

Object of class Student created by setupStudent.

n1

Either the sample size of the first stage (if recalculation = TRUE or the toal sample size (if recalculation = FALSE).

nuisance

Value of the nuisance parameter. For the Student's t-test this is the variance.

recalculation

Should the sample size be recalculated after n1 n1 patients are recruited?

iters

Number of simulation iterations.

seed

Random seed for simulation.

allocation

Whether the allocation ratio should be preserved exactly (exact) or approximately (approximate).

...

Further optional arguments.

Details

The method is only vectorized in either nuisance or n1.

Value

One type I error rate value for every nuisance parameter and every value of n1.

Examples

d <- setupStudent(alpha = .025, beta = .2, r = 1, delta = 3.5, delta_NI = 0,
                  alternative = "greater", n_max = 156)
toer(d, n1 = 20, nuisance = 5.5, recalculation = TRUE)