blindrecalc {blindrecalc}

Blinded Sample Size Recalculation

Description

The package blindrecalc provides characteristics and plots of trial designs with blinded sample size recalculation where a nuisance parameter is estimated at an blinded interim analysis.

Details

Currently, for continuous outcomes, a t-test is implemented for superiority and non-inferiority trials. For superiority trials with binary endpoint, the chi^2-test is implemented. The Farrington Manning test covers non-inferiority trials with binary endpoint.