Breast {biospear}

Early breast cancer data

Description

Breast contains clinical and genomic data of 614 early breast cancer patients.

Usage

data(Breast)

Format

A dataframe with variables:

time

Distant-relapse free survival time (in years).

status

Distant-relapse free survival indicator (0 = censored, 1 = event).

treat

Treatment arm (Anthracycline-based adjuvant chemotherapy with (treat = +0.5) or without (treat = -0.5) taxane).

...

All other covariates (p=1689) are gene expression values.

References

Desmedt C, Di Leo A, de Azambuja E, Larsimont D, Haibe-Kains B et al. Multifactorial approach to predicting resistance to anthracyclines Journal of Clinical Oncology 2011;29:1578-86. doi:10.1200/JCO.2010.31.2231
Hatzis C, Pusztai L, Valero V, Booser DJ, Esserman L et al. A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. Journal of the American Medical Association 2011;305:1873-1881. doi:10.1001/jama.2011.593
Ternes N, Rotolo F, Heinze G and Michiels S. Identification of biomarker-by-treatment interactions in randomized clinical trials with survival outcomes and high-dimensional spaces. Biometrical journal. In press. doi:10.1002/bimj.201500234

Examples

  library(survival)
  data(Breast)
  dim(Breast)
  
  km <- survfit(Surv(time, status) ~ treat, data = Breast)
  km
  plot(km, col = c("black", "red"), lwd = 2, xlim = c(0, 5), xaxt = "n", yaxt = "n")
  legend("bottomleft", legend = c("Control", "Experimental"), col = 1:2, 
    lty = 1, lwd = 2, cex = 1.5)
  axis(1, cex.axis = 1.3)
  axis(2, las = 2, cex.axis = 1.3)
  mtext("Distant-recurrence free survival", side = 2, line = 3.2, cex = 1.5)
  mtext("Time (in years)", side = 1, line = 2.5, cex = 1.5)