Sensitivity Analysis and Optimum Experiment Design for Microbial Inactivation


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Documentation for package ‘bioOED’ version 0.2.1

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calculate_FIM Calculation of Fisher Information Matrix
calculate_isothermal_FIM Fisher Information Matrix for isothermal experiments
calculate_limit "Detection" limit for each model
calculate_pars_correlation Correlation Between Model Parameters Sensitivities
criterium_Amod_iso Objective function for A modified-optimal OED with detection limit
criterium_A_iso Objective function for A-optimal OED with detection limit
criterium_D D Optimality Criterium
criterium_D_iso Objective function for D-optimal OED with detection limit
criterium_Emod_iso Objective function for E modified-optimal OED with detection limit
criterium_E_iso Objective function for E-optimal OED with detection limit
criterium_modE Modified-E Optimality Criterium
detection_bigelow Detection limit of the Bigelow model
detection_mafart Detection limit of the Mafart model
detection_peleg Detection limit of the Peleg model
detFIM Objective function for D-optimal OED
get_detection Calculate detection limit
get_isothermal_correlation Parameter correlation for isothermal inactivation experiments
inactivation_OED Optimum Experimental Design of Microbial Inactivation
inactivation_OED_penalty Optimum Experimental Design of Microbial Inactivation with Penalty
inactivation_sens_handler Handler for the calculation of sensitivities of inactivation models
isothermal_OED Optimal Experiment Design of isothermal inactivation
isothermal_OED_limit OED of isothermal microbial inactivation with detection limit
isothermal_sensitivities Local sensitivites of isothermal microbial inactivation
objective_D Objective Function for the D Criterium
objective_D_penalty Objective Function for the D Criterium with Penalty
objective_Emod Objective Function for the modified-E Criterium
objective_Emod_penalty Objective Function for the modified-E Criterium with Penalty
optimize_refTemp Optimization of the Reference Temperature
penalty_function Penalty Function for OED
plot.IsoSensitivities Plotting of IsoSensitivities objects
plot.OEDinactivation Plot of OEDinactivation
plot.OEDisothermal Plot of OEDisothermal object
plot.parCorrelation Correlation Plot of Parameter Sensitivities
refTemp_optim_handler Hanlder for the Optimization of Reference Temperature
sensitivities_Bigelow Local sensitivities of the Bigelow model
sensitivities_Mafart Local sensitivities of the Mafart model
sensitivities_Peleg Local sensitivities of the Peleg model
sensitivity_inactivation Local sensitivities of microbial inactivation