breast {beeswarm}

Lymph-node-negative primary breast tumors

Description

Tumor molecular measurements and outcome from breast cancer patients.

Usage

data(breast)

Format

A data frame with 286 observations on the following 5 variables.

ER

Estrogen receptor status (factor with levels neg, pos)

ESR1

Expression of the ESR1 gene (numeric)

ERBB2

Expression of the ERBB2 gene (numeric)

time_survival

Time in months (numeric)

event_survival

Coded event: 0 = censored, 1 = metastasis (numeric)

Details

ER, ESR1, and ERBB2 were measured on a tumor specimen taken at surgery (time = 0).

ESR1 and ERBB2 expression values were determined by microarray probe sets 205225_at and 216836_s_at using RMA-normalized data.

Source

Wang Y, Klijn JG, Zhang Y, Sieuwerts AM, Look MP, Yang F, Talantov D, Timmermans M, Meijer-van Gelder ME, Yu J, Jatkoe T, Berns EM, Atkins D, Foekens JA. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet. 2005 Feb 19-25;365(9460):671-9.

Examples

  data(breast)

  with(breast, 
    plot(ESR1, ERBB2, col = as.numeric(ER))
  )