toer {basksim}

Calculate the Type 1 Error Rate for a Basket Trial Design

Description

Calculate the Type 1 Error Rate for a Basket Trial Design

Usage

toer(
  design,
  n,
  p1 = NULL,
  lambda,
  design_params = list(),
  iter = 1000,
  data = NULL,
  ...
)

Arguments

design

An object created with one of the setup functions.

n

The sample size per basket.

p1

Probabilities under the alternative hypothesis. If NULL then the type 1 error rate under the global null hypothesis is calculated.

lambda

The posterior probability threshold.

design_params

A list of params that is specific to the class of design.

iter

The number of iterations in the simulation. Is ignored if data is specified.

data

A data matrix with k column with the number of responses for each basket. Has to be generated with get_data. If data is used, then iter is ignored.

...

Further arguments.

Value

A numeric value.

Examples

# Example for a basket trial with Fujikawa's Design
design <- setup_fujikawa(k = 3, p0 = 0.2)
toer(design = design, n = 20, p1 = c(0.2, 0.5, 0.5), lambda = 0.95,
  design_params = list(epsilon = 2, tau = 0), iter = 1000)