calculateHillAUC {basicdrm}

Calculate the area under the curve for a Hill dose response model

Description

The area under the curve, or AUC, is a commonly used and robust metric for evaluating and comparing dose response models. The area is calculated in a log-concentration space, and so is dependent not only on the concentration bounds, but also on the base of the logarithm used. By default, this function follows the common convention of using base 10.

Usage

calculateHillAUC(hpar, range, baseline = 0, logbase = 10)

Arguments

hpar

A four parameter vector specifying the Hill model. Parameter details are found in the documentation for evalHillModel()

range

A two element vector specifying the lower and upper bound of area being calculated

baseline

The reference baseline response around which the area is being calculated. The default value of 0 is generally the most intuitive choice, but a value of 1 (or 100 in percent) could be used if the dose-response model is fitting relative survival.

logbase

The base of the logarithm applied to concentrations

Value

A single value specifying the area under the curve in the given range

Examples

auc <- calculateHillAUC(c(1,3,0,75), c(0.05,10))

# Area *over* the curve in survival studies
aoc <- -calculateHillAUC(c(0.1,2,1,0.1), c(0.01,1), baseline=1)