freq_eval {alphabetr}

Calculate the precision, CV, and accuracy of frequency estimates

Description

freq_eval() will evaluated how well freq_estimate performed by calculating the precision and CV of the frequency estimates for the top clones and by determining the proportion of the top clones whose true clonal frequency lies in the 95-percent CI determined by freq_estimate

Usage

freq_eval(freq, number_skewed, TCR, numb_clones, prop_top)

Arguments

freq

The output of freq_estimate

number_skewed

The number of clones represent the top proportion of the T cell population by frequency (this is the same number_skewed argument used when create_clones is called)

TCR

The clonal structure of the simulated T cell population. This is obtained by subsetting the TCR element of the output of create_clones

numb_clones

Total number of distinct clones in the parent population

prop_top

The proportion of the population in frequency represented by the number of clones specified by skewed.

Value

A list with the precision, cv, and accuracy of the frequency estimation.