dual_discrim_shared_likelihood {alphabetr} | R Documentation |

## Calculate likelihood of two beta-sharing candidate alpha-beta pairs deriving from a dual clone

### Description

`dual_discrim_shared_likelihood()`

is used within `dual_top`

to calculate the likelihood that two alpha-beta pairs identified by
`bagpipe`

sharing the same beta chain derive from a two
distinct clones sharing the same beta chain dual-alpha clone (instead of
a single dual-alpha clone)

### Usage

```
dual_discrim_shared_likelihood(est1, est2, err, numb_cells, numb_wells,
binomials, multinomials)
```

### Arguments

`est1` |
Frequency estimate of the first alpha-beta clone |

`est2` |
Frequency estimate of the second alpha-beta clone |

`err` |
Mean drop error rate |

`numb_cells` |
Vector containing the number of cells per well |

`numb_wells` |
Vector containing the number of wells with the sample
sizes given by |

`binomials` |
Calculations of the needed binomial coefficients; this is faster in R than in Rcpp (from my own tests) |

`multinomials` |
Calculations of the needed multinomial coefficients; this is way faster in R due to vectorization |

### Value

A numeric containing the negative log likelihood

*alphabetr*version 0.2.2 Index]