GroupSequentialDesign-class {adoptr}

Group-sequential two-stage designs

Description

Group-sequential designs are a sub-class of the TwoStageDesign class with constant stage-two sample size. See TwoStageDesign for slot details. Any group-sequential design can be converted to a fully flexible TwoStageDesign (see examples section).

Usage

GroupSequentialDesign(n1, c1f, c1e, n2_pivots, c2_pivots, order = NULL, ...)

## S4 method for signature 'GroupSequentialDesign'
TwoStageDesign(n1, ...)

Arguments

n1

stage one sample size or GroupSequentialDesign object to convert (overloaded from TwoStageDesign)

c1f

early futility stopping boundary

c1e

early efficacy stopping boundary

n2_pivots

numeric of length one, stage-two sample size

c2_pivots

numeric vector, stage-two critical values on the integration pivot points

order

of the Gaussian uadrature rule to use for integration, set to length(c2_pivots) if NULL, otherwise first value of c2_pivots is repeated 'order'-times.

...

further optional arguments

See Also

TwoStageDesign for superclass and inherited methods

Examples

design <- GroupSequentialDesign(25, 0, 2, 25, c(1, 1.5, 2.5))
summary(design)

TwoStageDesign(design)